Mad Cow Disease

faon rodriguez vulnificus at msn.com
Tue Sep 3 05:03:24 EST 1996


The culprit behind mad cow disease is a prion. Prions are nude proteins
devoid of DNA and RNA. The etiopathologic effect of prions is in the 
ability to change conformations from alpha helices to beta pleated 
sheets. The question is how can prions be infectious particles and 
how do they propagate in brain tissue without violating the laws of 
biology. Prions are not viruses or bacteria, does how do they 
propagate. The thought is that contact of infectious sPrP (scrapie 
protein prions) with normal cellular prion proteins (cPrP) causes an 
aplified chain reaction fo the domino effect, thus propagating more 
sPrP. Comments faon at msn.com



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