Peptide - MHC associations

A. Hatton MIC4AH at
Fri Jan 17 07:35:07 EST 1997

Can anybody explain how a peptide vaccine works? Does it bin to free MHC 
molecules on a cell surface (as I have read)? I'm sure it must work also by 
starightforward phagocytosis by APCs. If this is so, are they degraded or do 
you have to administer them in a form that is degraded into the final 
immunogenic peptide?

Please help, I need this for my dissertation yet I cannot fing any reference 
as to how they are expressed by APC's.

Anthony Hatton

E-mail : bigtone at

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