TEM beta lactamase trivia question -Reply

Patricia Bradford BRADFOP at war.wyeth.com
Thu Apr 2 08:45:59 EST 1998

TEM is the first three letters of the patient's name (Temoniera) from whom
the first b-lactamase in E. coli was recovered. The original description of
TEM-1 is found in Datta et al., Nature 208:239-241, 1965.  Also see
Mederios, A. British Med. Bull. 40:18-27, 1984 for an old but excellent
review on the original plasmid mediated b-lactamases.

Hope this helps.

Patricia Bradford
Wyeth-Ayerst Research
Pearl River, NY

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