Bactericidal/Bacteriostatic combinations

goodbyelook at yahoo.com goodbyelook at yahoo.com
Fri Apr 17 13:35:19 EST 1998



Hi,
It is well established that the combination of a bactericidal
drug (eg. Beta-lactam antibiotics) with bacteriostatic drugs
(eg. tetracyclines) has an antagonistic effect; so usually, this
combination is not advised.

My question is: Is this true when combining the Quinolones (eg. ofloxacin)
with bacteriostatic drugs? Quinolones are bactericidal, but have a different
mode of action from that of the beta-lactams.

I hope someone responds.
Best Regards,
BM

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