Origin of AIDS

Jay Mone' jmone at MARAUDER.MILLERSV.EDU
Mon Feb 16 09:54:50 EST 1998


John,

Actually, Gallo dod not have that mich trouble finding cells in which 
HIV could replicate.  he found that CD4 positive T cells would support 
replication of the virus.  The problem was that the virus killed the 
cells so rapidly that he was unable to establish long term cultures 
for study.  Gallo eventually isolated persistently infected cells from 
continuos cell lines which suppoerted replication of the virus but 
were relatively refractory to the cytopathic effects of the virus.
As far as the HIV-polio link, even if HIV was present in Salk's cells, 
this virus could never have survived the inactivation process used by 
Salk.  HIV is not a particularly stable virus.  SV-40, on the other 
hand, is remarkably stable to chemical and physical incativation used 
at the time.
The genetic links between HIV visna etc., have been looked at.  
Phylogenetic trees are available in many reviews which shows little 
similarity between these virus at either the sequence level or genetic 
organization level (e.g. the types of regulatory genes found in these 
viruses).

Jay Mone'



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