The target of Triclosan

[J.R. Pelmont]

SParker <eparker at aros.net> wrote :

> I think it is a cytochrome P450 inhibitor. 

According to L.M. McMurry et al :
in Nature (August 6, 1998) 395, 531-532 
in FEMS Microbiol. Lett. (1998) 166, 305-309

Triclosan is a broad spectrum antibiotic considered as an inhibitor of
enoyl reductase, as enzyme catalysing an essential step in the
elongation of fatty acids in bacteria. Dioxygen is not a substrate for
this reaction.

ACP-CO-CH=CH-CH2-... + NADPH, H+ -> ACP-CO-CH2-CH2-CH2-...+ NADP+

(ACP means acyl carrier protein, the link with the growing acyl chain
being a thioester bond as in acyl-CoA; the double bond is in trans,
contrary to the double bonds of unsaturated fatty acids, that are
usually cis)
-- 
jean.pelmont at ujf-grenoble.fr
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