The truth is out there RE: answers to nerve regeneration

Andrew K Fletcher andrew.k.fletcher at naturesway.demon.co.uk
Sat Nov 28 10:04:49 EST 1998


3rd time lucky?

For people who are reading this for the first time, please view the 1st post
at the bottom of this message.


Hi everyone

We don't seem to be getting anywhere with trying to establish the origins of
circulation of cerebrospinal fluid within the central nervous system.
I did send out a request to other medical news groups for an up to date
explanation of CSF circulation, but to date nothing has been forthcoming.

So I have conducted an up to date search on Pub Med at

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m

Please find enclosed in Wordpad format a few abstracts (full copies
available through Pub Med), offered as a benchmark for further discussion.
Please keep this doc at hand for future references.

any problems with posting docs in this or any other formats please let me
know.

References to giraffe cerebrospinal fluid and blood flow  are of particular
importance and should be studied to appreciate further postings.

All comments welcomed at this point so scrape the mud off your boots and
feel free to enter this discussion.

Kind regards   Andrew K Fletcher

Email:  andrew.k.fletcher at naturesway.demon.co.uk


Appeal post

Any spinal cord specialists out there who could help with this discussion?

Posted under heading: The truth is out there

If so,
could we please have someone put on record the current accepted mechanism
for cerebrospinal fluid circulation and formation? We need to have an
accurate benchmark, so that a new theory for fluid transport may be offered
for discussion. It is my belief that a new understanding of this phenomenon
will reverse a complete spinal cord injury.


2nd Post

The flow of water in plants and trees is relevant to this discussion, it was
my interest in this that led directly to my working with spinal cord injury,
ms and other neurological conditions.
"
Frank, could you please summarise the content of 'this wonderful process'
referred to in your posting and its relationship with how water reaches the
leaves of trees.

The flow of cerebrospinal fluid as described in Principles of Anatomy and
Physiology is as follows.

The entire central nervous system contains  between 80 and 150 ml (3 to 5oz)
of cerebrospinal fluid, colourless fluid of watery consistency. Chemically
it contains, proteins, glucose, urea and salts. It also contains some
lymphocytes.

With regard to its circulatory function, cerebrospinal fluid delivers
nutritive substances filtered from the blood to the brain and spinal cord
and removes wastes and toxic substances produced by brain and spinal cord
cells.

It then goes on to illustrate the path of the circulation of CSF.

The flow of cerebrospinal fluid as described in Advanced Human Biology: J.
Simpkins, J.I.Williams, is as follows.

Pressure compensation
CSF is produced from and returns to the blood passively in response to
pressure differences between the blood and CSF. The effects of increases in
blood pressure distending intercranial vessels can thus be reduced as more
CSF is produced.

Page 125 The beating of the cilia cells sets up currents in the
cerebrospinal fluid, thus helping the circulation of metabolites. Astrocytes
are connected to the bases of ependymal cells which may assist exchange of
metabolites between CSF and neurons in the central nervous system.

Fig 14.43, page 285 shows a simple drawing which illustrates the circulation
of fluids by arrows from the choroid plexus down one side of the spine and
up another side, it also shows a flow over the the surface of the brain,
indicated by an arrow on both sides.

I did read an article, which was a reprint of text from another physiology
book, which I can't find, that stated something along these lines.
Circulation in the CSF occurs due to respiration, postural, and circulatory
influences.

Ken Collins wrote:

I've not studied it, but I expect the cerebrospinal fluid flows through
active
dynamics... when it's produced, it goes into the ventricles, more is
produced...
what was produced earlier flows to "get out of the way" of what's just been
produced. I don't know where the "drain" is... expect it's a distributed
thing,
too. ken Collins

Original post.

>>Could someone therefore sum up the accepted mechanism for circulation
>in the
>>cerebrospinal fluid, so that we have an independent benchmark for
>further
>>discussions? Only then will we see if this road leads us to any
>conclusions.
>


>However, I too am interested in CSF, and attended a satellite
>conference (sponsored by NSF, prior to the Society for Neuroscience
>meeting early this month) on CSF as a communications system.  Among
>other things, problems of its circulation were considered.
>F. Frank LeFever, Ph.D.
>New York Neuropsychology Group




1st post

I hope to bring into this group some fresh arguments and evidences and
expect a certain amount of flack in the process.

I have listened to the arguments presented in the strings on this group and
feel that the activity in neuroscience and biology here may be a reasonable
platform to
throw in a few lions.

I would like to ask a few simple questions which will in due course lead us
to where my work in multiple sclerosis, Parkinson's disease and spinal cord
injury, began and is heading.

Your obvious knowledge and experiences in the nervous system outweighs my
own, so I hope you will put up with my ignorance in some aspects of future
discussion. And if I step of the line, which I intend to, please remember
this statement.
I intend to bathe in your experience and hope you too share my
hunger for knowledge.

Intro:
                                                        In The Beginning

Everything we are and everything we will ever become develops from a few
drops of fluid! How could circulation of these fluids begin in a chickens
egg for instance, or the seed of a tree? I have observed circulation taking
place in a developing embryo, long before the heart is formed. This was
shown a
a   couple of years ago on a TV documentary in the UK.

How does water really reach the leaves of trees? No working models exist
which demonstrate these very principles on which science is founded. If
osmosis, capillary action and root pressure are correct then show us how
they lift water to the top of a Canadian Redwood. After all they are all non
living physical forces.

If we want to understand the mechanisms involved in the nervous system,
should we not start right back at the beginning and attempt to identify the
origins of circulation within?

If we get lost on a journey we either continue blindly until the road stops
or we can retrace our steps until we know exactly where we are.

Could someone therefore sum up the accepted mechanism for circulation in the
cerebrospinal fluid, so that we have an independent benchmark for further
discussions? Only then will we see if this road leads us to any conclusions.

<364D7007.E5C6ADAA at pop3.concentric.net> K Collins wrote
Depending on environmental conditions, evolutionary dynamics go both ways...
all
"evolution" is optimisation with respect to the local energy gradient...
that's all genetics is, too.

It is within this statement albeit brief, that the truth exists. Once it is
appreciated that environmental factors are interacting with the circulation
of all bodily fluids, our reactions to weather patterns, and anything which
interferes with the gravitational pull of  Earth becomes of worthy
consideration.

I would like to enter into discussion also with Ken Collins, as his
layperson mode of writings reveals that he is committed to "T"ruth and is
prepared to go to prison for his beliefs! I wander how many more people
could say that?


kzelhart at mail.edge.net Wrote in message72s7c5$1mt at apple.telalink.net
>Stephan

I think the only point of any of this is a search for, and a continual
testing of the truth as we understand it. What is true for us today may
change because of evidence presented tomorrow. We must always question what
we know, else we become complacent and ignorant.

On this note I wish to end this message and begin this debate

Kind regards Andrew











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end




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