The target of Triclosan

Ariel / Jaime Finguerut ariel.finguerut at merconet.com.br
Sat Nov 28 16:36:19 EST 1998


Hello Jean:

Bonjour!
Thank you for the message.
I would like to know how to dissolve Triclosan and also Triclocarban in
water.
Does anyone know?
-----Mensagem original-----
De: J.R. Pelmont <Jean.Pelmont at wanadoo.fr>
Para: microbio at net.bio.net <microbio at net.bio.net>
Data: Quarta-feira, 25 de Novembro de 1998 20:42
Assunto: Re: The target of Triclosan


>SParker <eparker at aros.net> wrote :
>
>> I think it is a cytochrome P450 inhibitor.
>
>According to L.M. McMurry et al :
>in Nature (August 6, 1998) 395, 531-532
>in FEMS Microbiol. Lett. (1998) 166, 305-309
>
>Triclosan is a broad spectrum antibiotic considered as an inhibitor of
>enoyl reductase, as enzyme catalysing an essential step in the
>elongation of fatty acids in bacteria. Dioxygen is not a substrate for
>this reaction.
>
>ACP-CO-CH=CH-CH2-... + NADPH, H+ -> ACP-CO-CH2-CH2-CH2-...+ NADP+
>
>(ACP means acyl carrier protein, the link with the growing acyl chain
>being a thioester bond as in acyl-CoA; the double bond is in trans,
>contrary to the double bonds of unsaturated fatty acids, that are
>usually cis)
>--
>jean.pelmont at ujf-grenoble.fr
>Fax (33)0 476 51 4336
>




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