Colleagues, please review

Graham Shepherd muhero at globalnet.co.uk
Sun Oct 11 15:09:27 EST 1998


Brian M Burkhart wrote in message <361E6441.D485E11D at hwi.buffalo.edu>...
    Why,  if HIV does not cause AIDS, is it possible to clone out a section
of the HIV viral genome, express its protein, purify that protein,
crystallize that protein, determine the protein's 3D structure, design drugs
that block the action of that protein, and watch viral loads drop in
patients who take that drug.
    This was done with HIV protease. You know those miracle protease
inhibitors that have made the news all over the world and made those drug
manufacturers a lot of $$$.

    BMB

    --
Brian M Burkhart, Ph.D.
Hauptman-Woodward Medical Research Institute
73 High Street Buffalo, NY 14203
Phone: (716)856-9600 x313  FAX: (716)852-6086

    Answer: because you have produced a specific anti-viral treatment using
a known viral characteristic. You may have produced a successful treatment
for HIV infection, but you haven't proved anything whatsoever about AIDS.

    GS





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