What is Combinatorial Chemistry?
Dr. Duncan Clark
Duncan at nospam.demon.co.uk
Sun May 16 05:37:44 EST 1999
In article <7hkpdh$j8q$1 at remarQ.com>, Jose E. Calderon,P.E.
<jecalderon at cs-engineers.com> writes
> Is anyone there may explain what is Combinatory Chemistry?
In my simple mind I consider it like:
You find a compound but it has say side effects or say you want to
screen for new compounds starting from a known drug or chemical. What
you basically do is chemically synthesise, on a small scale, in an
automated or semi-automated manner 1000's upon 1000's of derivatives of
the original candidate compound. Each one is then tested for efficacy
etc. The big break-through is through the use of machines that will
accomplish this sort of synthesis in a fraction of the time chemists
took doing it manually.
The problem with being on the cutting edge is that you occasionally get
sliced from time to time....
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