What is Combinatorial Chemistry?

Dr. Duncan Clark Duncan at nospam.demon.co.uk
Sun May 16 05:37:44 EST 1999

In article <7hkpdh$j8q$1 at remarQ.com>, Jose E. Calderon,P.E.
<jecalderon at cs-engineers.com> writes
>    Is anyone there may explain what is Combinatory Chemistry?

In my simple mind I consider it like:

You find a compound but it has say side effects or say you want to
screen for new compounds starting from a known drug or chemical. What
you basically do is chemically synthesise, on a small scale, in an
automated or semi-automated manner 1000's upon 1000's of derivatives of
the original candidate compound. Each one is then tested for efficacy
etc. The big break-through is through the use of machines that will
accomplish this sort of synthesis in a fraction of the time chemists
took doing it manually. 

The problem with being on the cutting edge is that you occasionally get 
sliced from time to time....

Duncan Clark
DNAmp Ltd.
Tel: +44(0)1252376288
FAX: +44(0)8701640382

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