Review of "Penicillin: A Paradigm for Biotechnology"

R. I. Mateles rmateles at candida.com
Wed Feb 2 10:23:45 EST 2000


A reveiw of this book appeared in "Microbiology Today," the quarterly magqazine of the Society for General Microbiology.

The reviewer wrote, in part, "These fascinating papers are retained and two further chapters included bringing the penicillin up-to-date.  This text should be essential reading for both students and established scientists with an interest in industrial microbiology."

The book can be purchased from www.barnesandnoble.com

                     or                         www.amazon.com

                     or                         www.candida.com

See below for further details on the book.





Penicillin: A Paradigm for Biotechnology

Richard I. Mateles, Editor


Reprints The History of Penicillin Production, the classic publication of the American Institute of Chemical Engineers, originally published in 1970 and long out-of-print. It is updated by the inclusion of two new chapters dealing with scientific advances in penicillin biochemistry, microbiology, and genetics made since 1970; and the current commercial and industrial status of penicillin and its derivatives.


This book tells the remarkable story of penicillin's progress from a laboratory curiosity to being the first antibiotic available for regular use, and still a very important product today. The contributors to this book are the scientists and engineers who played the major role in that enterprise, which has served as a model for fermentation development for the last fifty years.


Among the penicillin program's "firsts," which continue to be important in biotechnology today, were:


mutation and selection for microbial strain improvement

scale-up of fermentors for aerobic processes

countercurrent liquid-liquid extraction    

industrial-scale lyophilization of sterile pharmaceuticals


Published: December, 1998 xi + 114 pp. ISBN 1-891545-01-9

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