DNA is NOT a helix

Rusty Cooper cooper_rusty at hotmail.com
Wed Feb 16 17:48:56 EST 2000


On 16 Feb 2000 14:57:20 EST, <biegel at concentric.net> wrote:

>I am new to user groups, and I hope therefore that this message reaches
>someone who is interested.  I seek a brave person with a DNA laboratory.
>
>I can prove that Form I DNA (i.e., "CCC" or covalently closed circular,
>duplex DNA) from native sources is generally NON-helical.
>
>Actually, this has been proven twice before, therefore I should say rather
>that I can prove DEFINITIVELY that native circular DNA is NOT, topologically
>speaking, a helix.
>
>But I can't do the work myself, because I have no lab, and I'm not a
>professional scientist.
>
>Anyone getting involved in this work stands to get famous, but also stands
>to be rather severely criticized.  People who challenge the "right-handed
>helix" tend to be ridiculed, and, if it's possible for them to be hurt
>(i.e., by cutting off of grant support), they may be hurt also.
>
>Therefore, I said above that I seek someone "brave", because you WILL be
>criticized for telling the truth.
>
>I also need someone with a laboratory.  To do the critical experiment you
>need access to good-quality (i.e., un-nicked) Form I circular DNA from a
>virus or plasmid, a pH meter, and apparatus for agarose gel electrophoresis.
>That's it!
>
>The experiment I will describe is so incredibly simple, you just won't
>believe that in 30 years, no one has seen fit to do it.  It takes 1 day.
>
>If you are interested, please contact me.
>
>Yours truly,
>
>K. Biegeleisen, M.D., Ph.D.

I have access to everything you describe and am interested in your
proposition.  Please get back to me.

RC




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