aberrant activation of 2-component signalling?
dalex at nexus.microimm.mcgill.ca
Thu Mar 30 15:21:34 EST 2000
I'm am looking for reagents which may non-specifically activate
procaryotic 2-component response regulator pairs: in vivo.
Does anyone know if such compounds exist?
I haven't been able to find published reports,
but perhaps there is some anecdotal evidence?
I am wondering about compounds that alter the fluidity
of cell membranes such that there is aberrant conformational changes
and activation of signal kinases, or compounds that non-specifically
phosphorylate response regulator proteins, or ...?.
Published reports suggest that the 2-component systems respond to a
small and specific set of congnate ligands (e.g. a single sugar,
amino acid, etc.). However, in my limited experience, biology is
much messier than that and compounds that activate multiple systems
Thanks for any clues,
dalex at microimm.mcgill.ca
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