tilmicosin

Tom McCloud mccloud-tom at worldnet.att.net
Sun Oct 21 17:50:24 EST 2001


On Fri, 19 Oct 2001 19:19:00 +0100, "scotratrescue"
<scotratrescue at ntlworld.com> wrote:

>Can anyone give me any info on cardiac toxicity of this drug, specifically
>for use in rats.
>searches not coming up with much.

Tilmicosin.  
   
hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-
  piperidinyl)tylosin; 
20-deoxo-20-(3,5-dimethylpiperidin-
1-yl)desmycosin; 
EL-870; LY-177370; 
  
Micotil (Elanco).  
C46H80N2O13; 
mol wt 869.15.  

C 63.57%, H 9.28%, N 3.22%, O 23.93%.  
  
  Macrolide antibiotic; structurally related to tylosin, q.v.  
Prepd as 85:15 mixture of cis/trans 
  isomers:  M. Debono, H. A. Kirst, Eur. pat. Appl. 
103,465; eidem, U.S. pat. 4,820,695 (1984, 1989 
  both to Lilly); M. Debono et al., J. Antibiot. 42, 1253 
(1989).  In vitro antibacterial activity: E. E. 
  Ose, ibid. 40, 190 (1987).  Metabolism and tissue 
residue studies in cattle:  A. L. Donoho et al., 
  ACS Symposium Series 503, 158-167 (1992).  Trial in 
treatment of calf pneumonia:  E. E. Ose, L. V. 
  Tonkinson, Vet. Rec. 123, 367 (1988).  Prophylactic 
efficacy in bovine respiratory tract disease:  D. 
  W. Morck et al., J. Am. Vet. Med. Assoc. 202, 273 
(1993).
  
        uv max:  283 nm (.epsilon. 22643).  pKa' (66% 
DMF):  7.4, 8.5. [.alpha.]D23 +12.75 deg (c = 0.010004 
in 
  CHCl3, 5 cm).

  
        THERAP CAT (VET):  Antibacterial.  





>
>anyone?
>
>Thanks
>
>Donna
>
>Scotrat Rescue
>




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