Pulmonary delivery of Antibodies

Emir Khatipov khatipovNO at NOuchicago.edu
Mon Jun 17 18:15:35 EST 2002


I don't know of any evidence produced so far that antibodies could have been
delivered via the lungs into the blood stream. What is the point of doing
that as compared to conventional i.v.? If you target is to topically
administer the therapeutic antibodies to lung or tracheal tissues (to treat
e.g.asthma), I would suggest to try crosslinking the antibodies to
transduction peptides, like TAT or antennopaedia. There are also other
commercial transd. peptides available on the market. These peptides have
been shown in a few (so far) cases to drag the proteins they are attached to
through the cell and nuclear membranes. If your antibodies are not targeted
toward intracellular proteins, but towards surface receptors or the like,
you might succeed in doing that without any transduction peptides. Just a
penny-worth thought.
- Emir

"Jon" <jberg at evitlabs.com> wrote in message
news:6031d413.0205151749.67e0183a at posting.google.com...
> I am looking to read about pulmonary delivery of antibodies.  I have a
> new simple device to create an instant aerosol that does not damage
> antibodies and can deliver to the deep lung.  Looking for data on what
> size of antibodies can transfer through to the bloodstream.  Thanks





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