On Fri, 29 Mar 2002 22:22:10 +0000, Jonathan Silverlight
<jsilver at merseia.fsnet.co.uk> wrote:
>>If you're thinking of the paper I think you are (it's on-line at the
>PNAS web site) they _didn't_ find infectivity at 1000C but they did at
>600C. Their theory is that some inorganic matrix survives at that
>temperature but not at 1000C.
I recall looking at that paper earlier. Intriguing, but the conclusion
is rather suspicious, and the data are sparse.
Has anyone either repeated this or followed up?
As an example of a concern... how do we know the T to which the prion
material was actually exposed? Poor heat transfer in some "corner" of
the apparatus, and, voila, survival. If I recall, the survival of
infectivity at 600 deg was low, so it wouldn't take much of a cool
spot in the apparatus.