Penicillin: A Paradigm for Biotechnology

Richard Mateles rmateles at earthlink.net
Mon Nov 10 17:11:25 EST 2003


       Penicillin: A Paradigm
          for Biotechnology



Richard I. Mateles, Editor



Reprints The History of Penicillin Production, the classic publication of
the American Institute of Chemical Engineers, originally published in 1970
and long out-of-print.   It is updated by the inclusion of two new chapters
dealing with scientific advances in penicillin biochemistry, microbiology,
and genetics made since 1970; and the current commercial and industrial
status of penicillin and its derivatives.



This book tells the remarkable story of penicillin's progress from a
laboratory curiosity to being the first antibiotic available for regular
use, and still a very important product today.  The contributors to this
book are the scientists and engineers who played the major role in that
enterprise, which has served as a model for fermentation development for the
last fifty years.



Among the penicillin program's "firsts,"  which continue to be important in
biotechnology today, were:



mutation and selection for microbial strain improvement

scale-up of fermentors for aerobic processes

countercurrent liquid-liquid extraction

industrial-scale lyophilization of sterile pharmaceuticals



Published: December, 1998      xi + 114 pp.     ISBN 1-891545-01-9

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To order a copy, mail this form (or fax to 312-431-1605) to: Candida
Corporation, Suite 1310, 220 South State Street., Chicago, IL 60604; or buy
on-line from www.amazon.com





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Candida Corporation
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