Yeast-Two-Hybrid System - Some questions

Scott Coutts SPAMFILTER-scott.coutts at med.monash.edu.au
Sun Nov 21 18:06:34 EST 2004


There's a lot of papers on this in medline isn't there?

Scott.

Michael Reiter wrote:

> Hi!
> STAT.......Signal Transducers and Activators of Transcription
> 
> SH2.........Src Homology
> 
> 
> Stats are the only known Transcriptionfactors containing a SH2 domain. Thus 
> the Signal transducing pathway is very short, since STATs are directly 
> activated by JAKs (Janus Kinases). Jaks are Receptors that do not 
> phosphorylate themselves but the STATs. Those STATs recognize each other via 
> their SH2 domain for Dimerization. (SH2 domains allow recognition of 
> tyrosinphosphates which are generated by the JAKs).
> 
> Hope this helps you!
> bye
> "Jorge1907" <jorge1907 at aol.comcomm> schrieb im Newsbeitrag 
> news:20041118171718.00480.00000841 at mb-m17.aol.com...
> 
>>Mike;
>>
>>I can't help you but would appreciate your explaining the terms:
>>         STAT
>>         SH2
>>
>>There are more things in heaven and earth, Horatio,
>>Than are dreamt of in your philosophy 
> 
> 
> 



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