Why is Streptomycin less effective against gram-positive bacteria?
JennyGibbs at Sheffield23.fsnet.co.uk
Wed Apr 13 14:48:37 EST 2005
I'm an A-Level Biology student and am in the middle of a Microbiology
I had to research and compare the effectiveness of Streptomycin against a
gram positive (Staphylococcus albus) and a gram-negative (E.coli) bacteria.
I found that Streptomycin was significantly more effective against the
gram-negative strain, a pattern supported by background research. I know
that Streptomycin works by inhibiting protein synthesis but can't see why
this would be more effective against gram negatives than gram positives,
particularly given the fact that gram-negatives have the second outer
membrane to inhibit the entry of chemicals into a cell.
Can anyone help please?
I will make due reference to any help in the Bibliography section of the
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