[Microbiology] Re: Methyl-Citrate-Cycle - Context and Questions

Keno Maerz Dr.K.No at gmx.de
Sun Mar 5 08:06:15 EST 2006


Bob schrieb:

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11294638&query_hl=2&itool=pubmed_DocSum
> 
> This talks about one step in the pathway you suggest, for Salmonella
> growing on propionate. This prompted me to quickly look at some other
> things I have. My sense is that this is a fairly recent discovery. A
> source not much older than this article said that propionate
> catabolism was not well understood, but probably went thru succinate
> or pyruvate.

Whew, difficult to read, but that one didn't cover what I was looking 
for. But, as I just found out, this recovery is in fact recent.

> So I now admit there does seem to be such a cycle, probably fairly
> recently discovered. But I will remain skeptical that this is the main
> pathway that most organisms use for the small amount of propionate
> they get from long chain odd-C FA. Perhaps what was well known is no
> longer true, but I would want to see the evidence. 

Also true, in fact this seems to be the way that is not commonly used.


> If all else fails, go eat some Swiss cheese, and see what happens.

Mhmm, I love swiss cheese.!


> Ah, also see
> http://content.febsjournal.org/cgi/content/abstract/268/12/3577

Ahh, this one finally solved my problem. I know enough now to get the 
comtext right I think. As soon as I got all of it pieced together, I'll 
post an abstract about what I learned, If you wish. Thanks a lot, you 
really have been a big help to me.

All the best,
Keno


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