molecular clocks

Marc Roussel mroussel at
Sun Sep 8 13:11:54 EST 1991

In article <9109081355.AA14144 at>
joe at GENETICS.WASHINGTON.EDU (Joe Felsenstein) writes:
>   The actual formula for probability of fixation of a mutant is (to
>extremely good approximation) given by Kimura's formula:
>     Prob(fixation)  =  (1 - exp(-4Nsp))/(1-exp(-4Ns))
>with p = 1/(2N) if the mutant is initially present in one copy (s is the
>increase in fitness in the heterozygote carrying the mutant).

     I would like to know more about this equation.  Is it an empirical
law?  If not, what assumptions go into it?  Can anyone provide us with a
reference that discusses and/or derives this law with a minimum of


				Marc R. Roussel
                                mroussel at

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