Query about long stretches of sequence identity

Ron DeBry debry at ds1.scri.fsu.edu
Thu Sep 26 15:31:45 EST 1991


In article <CMM.0.88.685908696.kristoff at genbank.bio.net> kristoff at GENBANK.BIO.NET (Dave Kristofferson) writes:
>What is the longest stretch of sequence *identity,* not just similarity, 
known between the mouse and bovine versions of the same protein?

As a minimum, start with 135 amino acids.  This is the length of histone
H3.  All mammals have two forms differing by one serine-cystein change
at position 96.  Interestingly, in human and cow, 80% of the protein is
H3.1, but in rodents 80% of the protein is H3.2.

The other histones are similar in size, and probably also have identical
variants in both cows and rodents.

I don't have the exact reference off the top of my head, but every 2-3
years Dan Wells publishes a big compilation of all histone sequences in
the supplement to NAR.

Ron DeBry

debry at ds1.scri.fsu.edu



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