RIPPING

David Rand DRAND at BROWNVM.BROWN.EDU
Sat Apr 25 22:57:12 EST 1992


OK net fiends,
     Can anyone steer me to some old or recent literature on repeat
induced point mutations?  I've got some sequences that have an apparent
excess of point substitutions, deletions, insertions, etc. in a GC rich
dyad symmetric sequence.  There are lots of nice polymorphisms within
species and rapid divergence between species.  I'm not so sure the DNA
is RIPPING; it might only be RAPPING (Repeat Associated Point mutations)
Thus:
     Yo, I've got some DNA that does seem to be a-rippin'
     My dog is so excited her saliva is a-drippin'
     she thinks that the polymerase is doing some a-skippin'
     but then again, you never know, she might be just a-quippin'

     Are you sure induction by repeats did make it happen?
     If its just association why not call it RAPPIN'
     What motifs are necessary to keep the strands a-snappin'?
     I dont know and I dont care, but something sure did happen.

See you at Penn State and Bezerkeley?

drand at brownvm.brown.edu
(401) 863-2890



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