Evolution of the immune system

adavies at vax.path.ox.ac.uk adavies at vax.path.ox.ac.uk
Tue Dec 8 01:55:27 EST 1992


In article <ByoqD6.Fwq at gpu.utcs.utoronto.ca>, lamoran at gpu.utcs.utoronto.ca 
(L.A. Moran) writes:
>          Very few of the molecules of the vertebrate immune system have an
> evolutionary history that predates the origin of chordates, this suggests
> that most of the vertebrate immune system is fairly new on the scene.

But isn't a notable exception MHC class II, which shows homology to poriferan 
non-self recognition molecules?
Basic experiment is to put two sponges of different species through a sieve 
(ouch!) - they then reassort into the two different species as before.

I think this (and the class II) homology is amazing!!  Anyone know more...

Anthony Davies
Institute of Virology and Sponging
Mansfield Road
Oxford UK



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