re - substitution rates

[Francisco J. Ayala]

There's an excellent program by Prof. Richard Lewontin at Harvard
that analyzes DNA sequences, providing the number of replacement
and synonymous substitutions, as well as a variety of related
statistics.  The program is called SynSub.  Here is the reference:

Lewontin, R. C. 1989. "Inferring the number of evolutionary events
from DNA coding sequence differences" Mol. Biol. Evol. 6(1):15-32.

Good luck,
Ze' Ayala