DNA heterozygosity

bickle at urz.unibas.ch bickle at urz.unibas.ch
Fri Jan 14 08:56:46 EST 1994


In article <CJKznL.675 at news.udel.edu>, mcdonald at strauss.udel.edu (John H McDonald) writes:
> In article <2h3qjm$24m at hahn.informatik.hu-berlin.de>,
> Dirk Balfanz <balfanz at informatik.hu-berlin.de> wrote:
>>
>>has anybody out there got any figures from any recent publications, or 
>>even old (if reliable) that show heterozygozity of the human genome for
>>1) protein coding sequences (exons)
>>2) intervening sequences (introns)
>>3) noncoding regions
> 
> Li, W-H. and L.A. Sadler. 1991.  Low nucleotide diversity in man. Genetics
> 129: 513-523.
> 
> The authors of this paper looked through the databanks for genes that had
> been sequenced more than once, and came up with estimates of nucleotide
> diversity for exons, introns, etc.  One of the take-home messages was that
> nucleotide diversity in humans was very poorly known.  I don't know if
> there are more recent papers on the subject.
> 
> John H. McDonald
> Department of Biology
> University of Delaware
> 

I believe that the Li and Sadler paper is probably documenting sequencing 
errors rather than heterozygosity.

-- 
Tom Bickle
Microbiology Dept, Biozentrum, Basel University
Klingelbergstrasse 70, CH-4056 Basel, Switzerland
+ 41 61 267 21 20       bickle at urz.unibas.ch



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