Mutation tables.

unknown at dl.ac.uk unknown at dl.ac.uk
Tue Jan 18 10:09:44 EST 1994


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  John Drake has been collecting and computing mutation rates in
          different organisms.  He can be reached at:
          Laboratory for Molecular Genetics
          E3-01, NIEHS
          PO Box 12233
          Research Triangle Park
          NC 27709-2233
          Tel: (919) 541-3361

          Philip Harriman, NSF



        Where can I find tables of naturally occurring mutation rates?

I want to know:
        What is the ratio of C -> T mutations : A -> G mutations in
various species?
        Is the excess rate of C -> T mutations completely accounted
for by CpG methylation?  Or is that only part of the reason for
an elevated rate of C -> T compared to A -> G?
        What are the ranges of values for the ratio of silent mutations
within coding regions to amino acid-substituting mutations?  i.e.
if I find 703 mutations in a gene between species A and species B and only 3
amino acid changes in the proteins of species A and B, is this very
unusual?


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*  Brian Foley               *     If we knew what we were doing   *
*  Molecular Genetics Dept.  *     it wouldn't be called research  *
*  University of Vermont     *                                     *
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