NEED: Tree alignment of Protein sequences
Georg Fuellen
fuellen at math10.Mathematik.Uni-Bielefeld.DE
Fri Jul 22 10:45:01 EST 1994
In article <CtArB2.CKH at hermes.hrz.uni-bielefeld.de>, I wrote:
|> Is there any paper featuring a tree alignment of protein sequences ??
|> (i.e. an alignment with reconstructed ancestral sequences)
|> All I could dig out so far were tree alignments of RNA sequences
|> and non-tree multiple alignments.
|>
|> Of course, an electronically accessible tree alignment would be
|> just marvellous...
|> Or maybe you can email such a thing to me ?
Let me explain what I meant with "tree alignment":
Given a phylogenetic tree, you may calculate a multiple alignment.
But I need the ancestral sequences be calculated as well, i.e.
the inner nodes of the phylogenetic tree must be labeled as well :
root ALWVG <----------------------------
/ \
AL-LL <- LLWVG <-
/ \ / \
AL-LL GL--L LLWVG LL-VG
Now the corresponding __tree alignment__ is
ALWVG (*) <-----------------------------------------------
AL-LL (*) <-
LLWVG (*) <-
AL-LL
GL--L
LLWVG
LL-VG
where "<-" indicates reconstructed sequences. (artificial example)
georg
fuellen at Mathematik.Uni-Bielefeld.DE
fuellen at MIT.EDU
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