mechanisms for simple dominant pattern of inheritance

Howard M. Bomze hb10+ at andrew.cmu.edu
Thu Mar 17 14:38:32 EST 1994


I think most simple dominant phenotypes are probably due to the
resessive alelle being a null, that is no product or a non-functional
product.  If a protien is made but does not contain the DNA binding
domain then it can not function if it needs to bind DNA.  Another
possibility is if a mutant protien which can function but functions
improperly is produced, however the wild type protein can out compete it
for DNA binding sites then the mutant protein does not get a chance to
produce a mutant phenotype.  I don't know if this is very clear or not, 
I'll try and clear it up in a later post.



                                                    Howard Bomze



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