Transition/Transversion Ratios

Elliot Lefkowitz Lefkowitz at orion.cmc.uab.edu
Thu May 12 09:50:46 EST 1994


It seems to be taken as given in the literature discussing nucleotide
sequence mutagenesis, that transition mutations generally predominate over
tranversions. What I have missed in all the papers that take this as an
axiom is any reference to a publication that rigorously examined this
question. Can anyone point me to such a reference? Is there sufficient
evidence to conclude that transitions do predominate over transversions, or
were these conclusions reached (and then taken as gospel) by analysis of a
much too limited dataset?

Elliot

******************************************
*        Elliot J. Lefkowitz, Ph.D.      *
*          University of Alabama         *
* Biological Computing Resource Facility *
*        Department of Microbiology      *
*        Birmingham, AL 35294-2170       *
*                                        *
*        Lefkowitz at orion.cmc.uab.edu     *
******************************************



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