recombinase genes and viral transfer

Ralph M Bernstein ralph at ccit.arizona.edu
Wed Mar 8 08:11:24 EST 1995


Hi everyone, I posted this a week or so ago, but got very few responses and
no postings-help! someone must have some idea!  any ramblings will be
appreciated.
Ralph



>Hi all,
>I was wondering if any has hear of a higher eukaryotic gene organization such
>as this :

>2 genes, intronless, facing towards eachother (promotion-wise) that are
>absolutly critical for the function of a system.  these genes show no homology
>to eachother (or anyother genes for that matter) but are conserved for over 500
>million years of evolution.  they are absolutly critical for function.

>these are the recombinase activating genes.  they are essential for immune
>system function-t and b cell rearrangement.  a possible theory is that they are
>the resylt of horizontal gene transfer from a viral infection (intronless, 2
>genes for one function right next to each other on the same chromasome...ect) 
>500 million years ago or so.  they are almost completly conserved over this
>time.  

>question: can anyone support the viral introduction theory?
>          can anyone give me an example of any other system where 2 genes like
>this are essential for function, may have similar function (well maybe not
>similar but complimentary) and or are anything like this?

>i am really looking for any similarities anyone can propose, so ANY crazed
>sp[eculation is welcome! 


>if anyone has an idea, but needs more info just email me, 
>thx  ralph


Ralph M. Bernstein
Dept of Micro/Immuno
University of Arizona
Ph: 602 626 2585
Fx: 602 626 2100



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