testing if seqs. are in same phylo tre

Daniel Mcgoldrick ez005139 at chip.ucdavis.edu
Sun Nov 12 16:08:32 EST 1995


Hello David,

	If the sequences that you describe are proteins with the same function
but not derived from the same ancestral gene then perhaps they would be 
distributed on a different portion of the linkage map. I don't know if 
it is feasible in your system or what the copy number is, but if you 
perform a cross you can observe how the proteins segregate and assort and or 
try a complementation test if you have recessive phenotypes.

If the proteins fail to compliment in trans then they are the same gene 
at the same locus, but if the proteins assort independently then they are at 
different loci. If the proteins occupy the same locus then aren't they 
homologous? Otherwise they have either duplicated or are not homologous 
- perhaps recruited from another ancestral gene. Anyway, maybe you can take 
advantage of something external to the protein's own sequence to attack 
the question of homology.

						Cheers,
						Dan

_____________________________________________________________________________
Daniel J. McGoldrick				(707) 875-2076 Lab
U.C. Davis, Bodega Marine Laboratory 		(707) 875-2089 Fax me
P.O. Box 247
Bodega Bay, Ca. USA 94923
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