breaking codons?

Keith Robison robison at nucleus.harvard.edu
Thu Nov 16 17:40:57 EST 1995


Randy Zauhar (zauhar at xhost5.tripos.com) wrote:

:    Keith Robison wrote:

: >There really isn't much reason _a priori_ to expect recombination from
: >occuring amidst a codon.  Remember, the bulk of recombination involves
: >exact pairing between two pieces of DNA coding for about the same
: >thing, and so there are unlikely to be harmful effects from
: >the recombination event (i.e. recombination is unlikely to generate
: >a frameshift from two unframeshifted genes).

:    Sorry if this should be "common knowledge", but what is the probability
:  of introducing a frameshift during crossover? I have wondered about this,
:  but have never run across any estimates. I wonder if it is an effect that
:  can even be measured apart from other factors that introduce frameshifts?

Because pairing is almost always precise, frameshifts are almost
never introduced.  I don't know if anyone has really measured
it.

Keith Robison
Harvard University
Department of Cellular and Developmental Biology
Department of Genetics / HHMI

robison at mito.harvard.edu 






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