mtDNA integration into the nuclear genome

Keith Robison robison at mito.harvard.edu
Mon Sep 18 08:23:32 EST 1995


: In article <01HV2R1MTH4I8Y665K at gnv.ifas.ufl.edu>, CAMP at GNV.IFAS.UFL.EDU (Don Campton) writes:
: > Dear colleagues,
: > Please suggest references (original research papers, reviews, etc.) 
: > documenting the integration of mtDNA genes or sequences (e.g. D-loop)
: > into the nuclear genome, especially of vertebrates.  I am referring to
: > potential instances where the same or similar sequence (perhaps the
: > entire 16kb homologous sequence) occurs in both genomes.  This 
: > obviously would create PCR problems if one did not do a cell fractionation
: > step or CsCl separation of the two genomes prior to amplification.  Your
: > help will be appreciated.  Thanks.
: > Don Campton
: > Department of Fisheries and Aquatic Sciences
: > University of Florida

There's no shortage of papers on the subject.  You might try

http://atlas.nlm.nih.gov:5700/htbin-post/Entrez/query?uid=92046061&form=6&db=m&Dopt=m

for a quick entry into the literature via Entrez (in case you haven't
used it before, it's really great!  For each article of interest, 
click on the "Medline neighbors" link and you are likely to find
more articles which are similar in content).

Enjoy!


Keith Robison
Harvard University
Department of Cellular and Developmental Biology
Department of Genetics / HHMI

robison at mito.harvard.edu 





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