Preprint on line: SELF-ASSEMBLAGE OF GENE NETS IN EVOLUTION

Alexander Spirov spirov at iephb.ru
Thu Apr 18 10:52:17 EST 1996


        This announcement is being cross-posted to several newsgroups.
        Please, excuse the duplication.

Dear All,

The following paper is now available as ZIP-compressed
PostScript file via anonymous ftp from:

ftp://ftp.iephb.ru/pub/spirov/selfassembl.zip

and as HTM(L) Pages:

URL:  http://www.iephb.ru/selfass0.html

URL:  http://avs.iephb.ru/selfass0.htm

Interactively:
        ftp ftp.iephb.ru
        login: anonymous
        Password: <your_e-mail_address>
        cd pub/spirov
        binary
        get selfassembl.zip
        quit

        The pub/spirov/index file contains an index of the other files.

These materials are submitted for THE FOURTH INTERNATIONAL CONFERENCE ON 
PARALLEL PROBLEM SOLVING FROM NATURE (PPSN IV) 
BERLIN, SEPT., 1996. Any comments and criticisms are 
most welcome.

Title: "SELF-ASSEMBLAGE OF GENE NETS IN EVOLUTION VIA 
	RECRUITING OF NEW NETTERS "

Author: Alexander V. Spirov

ABSTRACT

To understand the conditions under which mutations and selection can lead 
to rising level of organization is of importance for evolutionary biology 
as well as in evolutionary computations. It is well-known that biological 
morphogenesis is the result of a cooperative self-regulating, 
self-organizing processes that is controlled by the genome. That is why 
many of the new developments of GA's begin to use hybrid systems which 
model both the self-organizing and selective mechanisms of biological 
systems.
What is more, we must take into consideration two aspects of the 
self-organisation mechanisms in evolution. First aspect has been working 
out by some authors and deals with self-organising mechanisms of the 
genotype-phenotype presentation. Second aspect will be discussed here. 
According to it, self-organization become apparent in evolution as 
self-assemblage of the gene networks and cascades.
This paper describes our first steps toward a biologically defensible model 
of evolutionary growth of Drosophila segmentation gene network. The 
identification of controller genes has been a significant recent finding in 
developmental biology. Networks and cascades of controller genes serve to 
orchestrate expression of the genome during embryo development. We use 
up-date knowledge about structure, function and evolution of real gene 
networks for the purposes of computer simulation of the networks 
self-organization in evolution. Our computer simulations of evolution of 
gene networks governing the embryo morphogenesis show possibility for 
self-organization or self-assemblage (or "outgrowth") of the networks. This 
self-assemblage proceeds by means of recruiting of new genes via closing up 
of new functional circuits between new and old members of the network.

KEYWORDS: self-organisation, evolution, genetic algorithms, 
genotype-phenotype presentation, gene networks, artificial life, 
evolutionary biology.

(13 pages, 13 color illus.)

	PS: The PS-file was generated by WinWord 7 and tested
by GhostScript viewer for Windows. 

Alexander V.Spirov (PhD)
I.M.Sechenov Institute of Evolutionary Physiology &
 Biochemistry, S.-Petersburg, Russia
phone/fax +7 (812)552 3219;  fax + 7 (812)552-3012
WWW http://avs.iephb.ru
Spirov at iephb.ru




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