Maximum Likelihood Analysis Question

higgins at ebi.ac.uk higgins at ebi.ac.uk
Thu Aug 22 06:52:35 EST 1996


In article <32195115.7240 at vims.edu>, Mark Siddall <mes at vims.edu> writes:
> Ron Kagan wrote:
>> 
>> For those of you who have used maximum likelihood analysis (DNAML and
>> DNAMLK of Felsenstein's Phylip package): What level of significance do
>> you use for the likelihood ratio between the log likelihoods w and w/o
>> the molecular clock, to reject the null hypothesis of the molecular
>> clock?  Is p<0.05 still the standard, or should I use a stricter criteria
>> (p<0.01)?
> 
> Sorry?!!
> Since when is the molecular clock a reasonable null hypothesis?!!!
> 

Since the early 1960s.


Des Higgins


> Molecular phylogenetics in the late 20th century... limited by the 
> arbitrariness of Joe Felsenstein's imagination and Linus Pauling's 
> presumptions???
> 
> [no offense Joe... ].
> 
> Mark



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