Codon Bias

Keith Bradnam keith at evol.nott.ac.uk
Thu Feb 8 06:25:29 EST 1996


Jeffrey J. Huckaby wrote:
> 
>         I am interested in codon bias as a combinatorial optimization
> problem...in some organisms, "optimal" codon usage appears to be
> correlated with the level of gene expression--highly expressed genes use
> the optimal codons whereas genes with lower expression use rare codons.
> Essentially, I am interested if this pattern results from a complex
> optimization process?
> 
>         Does anyone know of any articles on this issue?
> Thanks in Advance
> Jeff

Try looking in:
Nucleic Acids Research, 1994, Vol 22, No 14, pp 2437-2446 
for an article on codon usage bias in Caenorhabditis elegans.  Or for a more general paper,
look at:
Phil. Trans. R. Soc. Lond. B., 1995, Vol 349, pp 241-247

There are many more articles looking at codon usage bias in specific organisms, but you
should be able to pick out suitable references from the above papers.

Email me if you need to know any more on this, I'm looking at codon usage bias at present.

Keith Bradnam



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