Senapathy Theory -- Introns and Split genes

Periannan Senapathy sena at genome.com
Thu Feb 15 17:08:21 EST 1996


Friends:

Last spring I announced a new theory on the origin of life and 
its disparity on earth by the title "Independent Birth of 
Organisms."  Subsequently, during spring and summer, an 
extensive discussion went on in sci.bio.evolution, 
bionet.molbio.evolution and other related 
forums on this theory.  

One of the major bottlenecks that the conventional evolution 
theory has to go through is that it cannot show how even one 
contiguous gene of the assumed original ancestral prokaryote-like 
cell could originate probabilistically on earth.  Furthermore, only 
if contiguous genes could originate in the first place, could the 
introns be inserted into them later.  I have countered that 
assumption, and have shown that it is the split-genes that are 
typically eukaryote-like that originated directly in the random 
primordial DNA sequences, wherein they occurred essentially 
fully-formed, and that the eukaryote-like cells were formed 
directly from the genomes that assembled from these genes.  

If this is true, then we should be able to show that the split-genes 
typical of eukaryotes could easily and abundantly occur within a 
reasonably small amount of random primordial DNA material.  
I have provided extensive computational simulation experiments 
in my book "Independent Birth of Organisms," demonstrating this 
premise.  Now Jeff Mattox, who was a strong supporter of my 
theory during the internet discussions last summer, has made 
available a web site, where users can interactively search for any 
given "gene" in a reasonably short random DNA sequence.  The 
gene will be in split form, and you will search for many different 
exons in pieces, just as they occur in a typical eukaryotic gene.  
The results will demonstrate to you that finding such a gene in a 
short random DNA sequence is very easy.  In fact it will show that 
almost any gene that you query for can be found within the same, 
comparatively very short random DNA sequence.  The search 
engine provides easy statistics and some visual graphics, easy to 
understand.  Due to computational limitations, the search engine 
uses relatively short "exons" of 10-nt or less, but the results for 
larger exons would differ only in scale.  Also, each 10 nt invariant 
DNA sequence is equivalent to an exon sequence of 200 
nucleotides with codon degeneracy and amino acid degeneracy 
incorporated into it.  Complete instructions and explanations 
are provided on the web site.

I am sure that this will provide a ground for further discussion on 
the origin of the structure of genes that directly pertain to the 
origin of life and organisms.  I invite you to use this program, and 
to analyze the extremely high probability of the occurrence of split 
genes in random primordial DNA material, as opposed to the 
extreme improbability of contiguous prokaryote-like genes.  

The web site that contains the exon search engine:

http://www.mattox.com/genome/exons.html

If you would like further information and analysis as to "Why 
are split genes easier to find?" please look at:

http://www.fullfeed.com/genome/ez2split.html

Thank you very much,

Periannan Senapathy





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