themmen at endov.fgg.EUR.NL
Fri Mar 1 09:09:06 EST 1996
We are dealing with a puzzling problem. Recently we have cloned a cDNA
from rat testis that is hormone regulated. The cDNA encoded a predicted
leucine rich protein of 745 amino acids. We are now sequencing the human
homologous cDNA. It also contains an ORF, but now comes the puzzle: at
the RNA level the percentage identity (80%) is higher than the percentage
of identical amino acids (72%). My conviction has been that it should be
the other way around because of the possibility of the third base in the
codon to be at least two-fold redundant.
Can somebody give us an idea?
Axel PN Themmen
Endocrinology & Reproduction
Erasmus University Rotterdam
themmen at endov.fgg.eur.nl
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