nucleotide substitutions among inbred strains

[Jun-Ichi Aikawa]

Hello,

If cDNA is isolated from some inbred strains of mice, any nucleotide
substitutions are usually observed?
Furthermore, how about Balb/c and A (or LAF1 which is F1 hybrid of A x
Leadon) mice? As Balb/c and A mice are generated from the same albino
random-bred mice, nucleotide substitutions can be still observed?

I welcome any comments and suggestions.

Thanks.

Jun-ichi Aikawa, Ph.D.
Division of Cellular and Molecular Medicine
University of California, San Diego