multigene family

[F.Schaap at FYS.UNIMAAS.NL]

Dear Netters,

I am (still) searching a a reliable method for calculating divergence time 
between members of a multigene family, with the members having different 
evolutionary rates? Between orthologous sequences synonymous substitution 
rates are fairly constant (3*10-9 per site per year), while nonsynonymous 
substitution rates range from 0.021-0.76*10-9. Between paralogous sequences 
the number of synonymous substitutions per site can not be accurately 
estimated.

Who has any suggestions?

Regards, Frank