Modeling molecular evolution

Airlie Sattler airlie at mindspring.com
Sat Jan 11 19:54:59 EST 1997


Dear molbio.evolution readers,

I am thinking about writing a program to model sequence evolution.
Basically I want to be able to (1) input a known sequence (2)mutate it
using a range of mutation rates and types(ie base pair changes,
insertions, deletions) (3) use my artificially created sequences as a
control group for alignment and phylogenetic analysis. Do you know if
someone has written a program which does this already? Do you know of any
papers or references where people attempted similar projects?

If I do go ahead with this project, I need to establish a reasonable range
of mutation rates / sequence generation (How to set my molecular clock).
If you know of any source for background mutation rates in different
organisms, that would be a great resource. Also any basic reference where
I could find the average size and cause of insertion and deletion
mutations would be helpful. 

Thank you for any feedback you might have about this project.

Sincerely,
Airlie Sattler 
(airlie at mindspring.com)



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