calculation divergence time in multigene family

F.Schaap at FYS.UNIMAAS.NL F.Schaap at FYS.UNIMAAS.NL
Wed Jan 15 04:21:51 EST 1997


Who knows a reliable method for calculating divergence time between members 
of a multigene family, with the members having different evolutionary rates?
Between orthologous sequences synonymous substitution rates are fairly 
constant (3*10-9 per site per year), while nonsynonymous substitution rates 
range from 0.021-0.76*10-9. Between paralogous sequences the number of 
synonymous substitutions can not be accurately estimated, so use of 
non-synonymous differences seems necessary.

Any suggestions?

Frank Schaap



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