sequence divergence puzzle

Donal Hickey dhickey at
Tue Feb 9 11:22:58 EST 1999

My guess is that the nucleotide sequences have biased composition. This can
result in a high level of similarity at synonymous sites.


Sam King wrote in message <78vf24$qmh at>...
>I am not an evolutionary biologist but I am in the middle of writing
>my thesis and have a problem understanding this information. I have
>two sialidase genes from streptococcus pneumoniae which are more
>conserved at the nucleotide level (60%) than the amino acid level
>(53%). I thought this was usually the other way round.
>Ive checked the synonymous/nonsynonymous values using jukes-cantor
>theyare 1.2+-0.25/0.46+-0.046.
> Does anyone have any ideas? or other examples like this?
>Sam king

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