Lower-than-expected linkage disequilibrium

Andrew Gyles syzygium at alphalink.com.au
Wed Sep 5 23:56:48 EST 2001


"Andrew Gyles" <syzygium at alphalink.com.au> wrote in message
news:9n0hqd$n37$1 at mercury.hgmp.mrc.ac.uk...
> An article in Am J Hum Genet 2001 Sep; 69(3): 582-589 reports
> lower-than-expected linkage disequilibrium between tightly linked markers
in
> humans.
>
> The authors suggest that the explanation is that "gene conversion
increases
> the apparent rate of recombination between nearby loci".
>
> Would not gene conversion on a large scale also reduce the sequence
> variation in the human population? As I understand the mechanism, when a
> gene is converted an allele is eliminated, so:
>
>    "widespread gene conversion = widespread allele loss".
>
> Andrew Gyles
>
A geneticist has kindly pointed out that gene conversion is not likely to
result in lower sequence variation unless the gene conversion is biased.

I would therefore be grateful for any reference to an evaluation of biased
gene conversion in any genome.

Andrew Gyles


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