[Molecular-evolution] Basic question

Hans hanspet at hotmail.com
Sun Nov 27 21:28:24 EST 2005


I have a probably dumb question

Does genome structure, or more precisely, its base composition and
things like mutation and substitution rates, vary between different
embryonic stages?

Well, Im trying to understand a bit about isochore structures in
different species. The basic arguments for their formation are either
selective or mutational. Either case, it involves some force acting on
the base composition of the whole genome, such that some parts have a
higher GC content than others. Regardless of the mechanism(s)
responsible (this is still a highly debated topic) my question is: is
the basic assumption that the same mutational or selective processes
that can lead to differences in base composition, synteny conservation,
variable mutation/substitution rates etc, occur on somatic and germ
cells?

So back to the first question. Have anyone looked at the DNA of germ
cells vs somatic cells at different stages of development? just to find
out if throughout the different stages there is no difference between
what is happening in germ cell's DNA and somatic cell's DNA.



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