From tekaia from pasteur.fr Thu Jan 7 11:57:27 2010 From: tekaia from pasteur.fr (Fredj Tekaia) Date: Fri Jan 8 08:27:40 2010 Subject: [Molecular-evolution] Bioinformatics and Comparative Genome Analysis course 2010 in Institut Pasteur Message-ID: <9E7DCDD6-3048-418B-B61A-8C8D25C6ED2E@pasteur.fr> ================================= Apologies, if you're receiving multiple copies ================================= Call for applications: Bioinformatics and Comparative Genome Analysis course July 5 – July 17, 2010 Institut Pasteur Paris - France http://www.pasteur.fr/~tekaia/BCGA2010.html With financial support from: Institut Pasteur International Network. Aim of the course: The main objectives of the course are to familiarize young scientists (Biologists/Computer Scientists/Mathematicians) with bioinformatics and genome data analysis skills and to encourage multi-disciplinarity by introducing: 1- advanced fundamental algorithms in bioinformatics; 2- their application in genome analyses; 3- and recent knowledge acquired from genomes studies and perspectives. The course is aimed at motivated Ph.D and Post-doctoral students, as well as young assistant professors and junior scientists in Academic Institutions, with background in Mathematics, Statistics, Biology or Computing, and who are involved in Bioinformatics and Genomes studies. Duration: Full time from July 5 to July 17, 2010. Location: Institut Pasteur Paris, 28 rue du Dr Roux, 75724 cedex 15 Paris, France. Accommodation and meals: Selected students from developed countries will be charged a participation of 1300€. There will be no charge for students from developing countries and Institut Pasteur International Network. Applications Deadline: March 20, 2010. More information about the course, how to apply and application form can be found at the following web page: http://www.pasteur.fr/~tekaia/BCGA2010.html Thank you for circulating this announcement. Best regards The Organizers: Odile Kalogeropoulos, Institut Pasteur Paris - France. Julie Thompson, IGBMC Strasbourg – France. Hugo Naya, Institut Pasteur de Montevideo - Uruguay. Fredj Tekaia, Institut Pasteur Paris - France. From cambridge from ana.uni-heidelberg.de Wed Jan 27 10:40:57 2010 From: cambridge from ana.uni-heidelberg.de (Sidney Cambridge) Date: Thu Jan 28 08:26:43 2010 Subject: [Molecular-evolution] Quantitating the degree of conservation Message-ID: <20100127164057.0fd6jpcdtwkcoo08@wwwmail.urz.uni-heidelberg.de> Dear all, I hope my question is not too trivial.... I am looking for a quantitative measure of the degree of genetic conservation - basically attaching a high value to highly conserved genes such as histones and low values to genes that are not very conserved. Ideally there would be a database for all genes of the mouse or human genome with a 'conservation' value for each gene. Does something like this exist ? Thank you very much in advance ! Best, Sidney ************************************************************** Dr. Sidney Cambridge University of Heidelberg Interdisciplinary Center for Neurosciences Im Neuenheimer Feld 307/Rm. 420 69120 Heidelberg Germany Tel: +49-6221-54-8687 What would you attempt to do if you knew you could not fail ? ************************************************************** From gilbertd from bio.indiana.edu Sun Jan 31 20:39:59 2010 From: gilbertd from bio.indiana.edu (Don Gilbert) Date: Mon Feb 1 08:44:31 2010 Subject: [Molecular-evolution] Re: Quantitating the degree of conservation References: Message-ID: THe various protein databases do clustering of genes. You might want to use the number of species or gene copies in a gene cluster as a measure of convervation. E.g. Uniprot's UniRef data set. http://www.uniprot.org/uniref/?query=histone&sort=score (max 5,345 genes at 50% identity) versus http://www.uniprot.org/uniref/?query=obp&sort=score (max 23 genes at 50% id) -- Don On 2010-01-27, Sidney Cambridge wrote: > > Dear all, > > I hope my question is not too trivial.... > I am looking for a quantitative measure of the degree of genetic > conservation - basically attaching a high value to highly conserved > genes such as histones and low values to genes that are not very > conserved. Ideally there would be a database for all genes of the > mouse or human genome with a 'conservation' value for each gene. > > Does something like this exist ? > > Thank you very much in advance ! > > Best, > Sidney