[Molecular-evolution] Re: Quantitating the degree of conservation

Don Gilbert via mol-evol%40net.bio.net (by gilbertd from bio.indiana.edu)
Sun Jan 31 20:39:59 EST 2010


THe various protein databases do clustering of genes.
You might want to use the number of species or gene copies in a gene cluster
as a measure of convervation.  E.g. Uniprot's UniRef data set.

http://www.uniprot.org/uniref/?query=histone&sort=score 
	(max 5,345 genes at 50% identity)
versus
http://www.uniprot.org/uniref/?query=obp&sort=score  
	(max 23 genes at 50% id)

-- Don

On 2010-01-27, Sidney Cambridge <cambridge from ana.uni-heidelberg.de> wrote:
>
> Dear all,
>
> I hope my question is not too trivial....
> I am looking for a quantitative measure of the degree of genetic  
> conservation - basically attaching a high value to highly conserved  
> genes such as histones and low values to genes that are not very  
> conserved. Ideally there would be a database for all genes of the  
> mouse or human genome with a 'conservation' value for each gene.
>
> Does something like this exist ?
>
> Thank you very much in advance !
>
> Best,
> Sidney



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