Antibody 3D Modeling

Hiroyoshi Ohba ohba at YL05HP.TB.NODA.SUT.AC.JP
Fri Oct 28 02:03:46 EST 1994


HELLO Netters;

        Is there any software which assembles three-dimesional structure of
antibody Fab?   Now, I am not familier with structural biology but like to
begin analyzing the effect of molecular modification of antibody.  I have
tried AbM of Oxford Molecular Ltd which has been developed by Prof. Tony
Rees's Lab.  It works on the stand-alone Silicon Graphics and HP
workstations. In my case on assembling human Fab from its amino-acid
sequence, enormous time (days) was required for caliculation.  Would you
suggest quicker softwares on faster machines, or software employing other
algorythms?  All of your comments are welcomed.
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Hiroyoshi Ohba, Ph.D.
Laboratory of Immunology,
Department of Biological Science & Technology,
Science University of Tokyo
2641 Yamazaki, Noda, Chiba 278 Japan                               
Tel: 471-24-1501 ext. 4429      FAX: 471-25-1841             
e-mail: ohba at yl05hp.tb.noda.sut.ac.jp
(domain name is y-el-zero-5hp not y-one-owe-5hp, sorry) 
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