Protein folding problem solved?

murphy kenneth p kpmurphy at blue.weeg.uiowa.edu
Sat Jun 10 09:47:34 EST 1995


In article <1995Jun10.043411.15159 at alw.nih.gov>,
Rick Venable <rvenable at deimos.cber.nih.gov> wrote:
>On 9 Jun 1995 11:15:57 -0400 Clifford Beall pontificated:
>> In the June issue of the Johns Hopkins Alumni magazine (I only quote from
>> the most authoritative scientific sources), it is claimed that the protein
>> folding problem has been solved by two Hopkins researchers: Rajgopal
>> Srinivasan and George Rose.  They have developed a computer program known
>> as LINUS that it is claimed can predict the folding of soluble globular
>> proteins.  The pictures that appear with the article are very impressive. 
>> It seems like this could be a massive discovery.  Would anyone with
>> knowledge of this work like to comment further?
>
>Several researchers have made this claim over the last few years, including
>Harold Scheraga, Peter Wolynes, and (as someone has already commented) Ken
>Dill.  I'd call it hyperbole; in most instances these methods can attain

Scherage has certainly made (and still makes) this claim, but I'm quite sure
that Dill has not.  Wolynes I'm not sure of...

Regards,
Kip

--
Dr. Kenneth P. Murphy				e-mail: k-murphy at uiowa.edu
Department of Biochemistry			office: (319)335-8910
University of Iowa				lab:  (319)335-7936
Iowa City, IA 52242            		        FAX:  (319)335-9570



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